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Continuous multi-domain phenotyping of knee osteoarthritis identifies independent structural and symptom axes and clinically invisible subgroups at elevated arthroplasty risk

Yosef Sourougeon, Gilad Nesher, Sagy Apterman et al.

2026-11 Vol. 34 Issue 11 Pages 1666-1680

DOI: 10.1016/j.joca.2026.07.011

Deciphering the RSPO3-NFATC1 switch in the bone-cartilage paradox: Genetic liability to osteoporosis protects against osteoarthritis by modulating subchondral bone compliance

Lei Peng, Jinliang Wei, Haoran Yang et al.

2026-11 Vol. 34 Issue 11 Pages 1577-1589

DOI: 10.1016/j.joca.2026.05.013

Retsat promotes synovial mesenchymal stem cell senescence and aggravates osteoarthritis by inhibiting the PPARγ/RXR heterodimerization pathway

Yanbin Shi, Song Wu, Chi Liang et al.

2026-11 Vol. 34 Issue 11 Pages 1602-1616

DOI: 10.1016/j.joca.2026.06.012

Development of an impingement induced, reversible degenerative meniscus tear animal model to analyze pathogenesis and potential recovery from meniscus degeneration

Yong Jun Jin, Sujin Noh, Hee-Woong Yun et al.

2026-11 Vol. 34 Issue 11 Pages 1590-1601

DOI: 10.1016/j.joca.2026.06.011

Synovial fluid delays delamination wear in immature bovine cartilage under pure cyclical compressive loading without sliding

H. Zhang, S. Kaltalioglu, J. Audric et al.

2026-11 Vol. 34 Issue 11 Pages 1568-1576

DOI: 10.1016/j.joca.2026.02.004

Retraction notice to “LB-104 evaluating a novel target in the treatment of osteoarthritis pain” [J. Osteoarthr. Cartil. (2024) 836]

Alice Gilbert, Lise Rabillier, Reza Sharif-Naeini et al.

2026-11 Vol. 34 Issue 11 Pages 1681

DOI: 10.1016/j.joca.2026.08.003

Signals for mineralization and inflammation are observed following treatment with fasinumab, a specific nerve growth factor inhibitor

Poulabi Banerjee, Stephen J. DiMartino, Haitao Gao et al.

2026-11 Vol. 34 Issue 11 Pages 1642-1652

DOI: 10.1016/j.joca.2026.07.005

Updated prevalence of radiographic and symptomatic hip osteoarthritis: Findings from the Johnston County Health Study

Simoni Tomar, Carolina Alvarez, Todd A. Schwartz et al.

2026-11 Vol. 34 Issue 11 Pages 1661-1665

DOI: 10.1016/j.joca.2026.07.009

Patients with knee osteoarthritis exhibit an abnormal three-dimensional lower limb phenotype: An EOS imaging study

Bo Wang, Yubo Liu, Dengfa Gao et al.

2026-11 Vol. 34 Issue 11 Pages 1633-1641

DOI: 10.1016/j.joca.2026.07.003

SMSC-EVs restore chondrocyte function through S1PR1–mTORC2–mediated mitochondrial fusion and GPS2–HDAC1–driven epigenetic regulation

Zijian Guo, Xingjia Mao, Zehua Wang et al.

2026-11 Vol. 34 Issue 11 Pages 1617-1632

DOI: 10.1016/j.joca.2026.06.013

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